九州大学大学院医学研究院神経内科学教室

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ACTIVITY REPORT活動報告

研究業績

2020年度業績

  • Zhao Y, Yamasaki R, Yamaguchi H, Nagata S, Une H, Cui Y, Masaki K, Nakamuta Y, Iinuma K, Watanabe M, Matsushita T, Isobe N, Kira J. Oligodendroglial connexin 47 regulates neuroinflammation upon autoimmune demyelination in a novel mouse model of multiple sclerosis. Proc Natl Acad Sci USA. 117(4):2160-2169. 2020. (IF 9.412)
  • Masaki K, Sonobe Y, Ghadge G, Pytel P, Lépine P, Pernin F, Cui QL, Antel JP, Zandee S, Prat A, Roos RP. RNA-binding protein altered expression and mislocalization in MS. Neurology: Neuroimmunology & Neuroinflammation, 7:e704. 2020. (IF 7.724)
  • Fujii T, Yamasaki R, Miyachi Y, Iinuma K, Hashimoto Y, Isobe N, Matsushita T, Kira J. Painful trigeminal neuropathy associated with anti-Plexin D1 antibody. Neurology: Neuroimmunology & Neuroinflammation, 7, e819. 2020. (IF 7.724)
  • Watanabe M*, Nakamura Y*, Isobe N, Tanaka M, Sakoda A, Hayashi F, Kawano Y, Yamasaki R, Matsushita T, Kira J. Two susceptible HLA-DRB1 alleles for multiple sclerosis differentially regulate anti-JC virus antibody serostatus along with fingolimod. Journal of Neuroinflammation, 17, 206. 2020. *Equal contribution. (IF 5.793)
  • Hayashida S*, Masaki K*, Suzuki SO, Yamasaki R, Watanabe M, Koyama S, Isobe N, Matsushita T, Takahashi K, Tabira T, Iwaki T, Kira J. Distinct microglial and macrophage distribution patterns in the concentric and lamellar lesions in Baló’s disease and neuromyelitis optica spectrum disorders. Brain Pathology, 30(6), 1144-1157. 2020. *Equal contribution. (IF 5.568)
  • Imamura T, Yanagihara Y, Ohyagi Y, Nakamura N, Iinuma KM, Yamasaki R, Asai H, Maeda M, Murakami K, Irie K, Kira J. Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer’s disease model. Neurobiology of Disease, 137, 104739. 2020. (IF 5.332)
  • Nakamura Y, Liu Z, Fukumoto S, Shinoda K, Sakoda A, Matsushita T, Hayashida S, Isobe N, Watanabe M, Hiwatashi A, Yamasaki R, Kira J. Spinal cord involvement by atrophy and associations with disability are different between multiple sclerosis and neuromyelitis optica spectrum disorder. Eur J Neurol. 27(1):92-99. 2020. (IF 4.516)
  • Watanabe M, Nakamura Y, Sato S, Niino M, Fukaura H, Tanaka M, Ochi H, Kanda T, Takeshita Y, Yokota T, Nishida Y, Matsui M, Nagayama S, Kusunoki S, Miyamoto K, Mizuno M, Kawachi S, Saji F, Ohashi T, Shimohama S, Hisahara S, Nishiyama K, Iizuka T, Nakatsuji Y, Okuno T, Ochi K, Suzumura A, Yamamoto K, Kawano Y, Tsuji S, Hirata M, Sakate R, Kimura T, Shimizu Y, Nagaishi A, Okada K, Hayashi F, Sakoda A, Masaki K, Shinoda S, Isobe N, Matsushita T, Kira J. HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data. Scientific Reports, 11(1):607. 2021 Jan. (IF 3.998)
  • Shinoda K, Matsushita T, Nakamura Y, Masaki K, Sakai S, Nomiyama H, Togao O, Hiwatashi A, Niino M, Isobe N, Kira J. Contribution of cortical lesions to cognitive impairment in Japanese patients with multiple sclerosis. Scientific Reports, 10, 5228. 2020. (IF 3.998)
  • Tanaka K, Matsumoto S, Yamada T, Yamasaki R, Suzuki M, Kido MA, Kira J. Reduced post-ischemic brain injury in Transient receptor potential vanilloid 4 knockout mice. Frontiers in Neuroscience, 14, 453. 2020. (IF 3.707)
  • Matsushita T, Masaki K, Isobe N, Sato S, Yamamoto K, Nakamura Y, Watanabe M, Suenaga T, Kira J, and the Japan Multiple Sclerosis Genetic Consortium. Genetic factors for susceptibility to and manifestations of neuromyelitis optica. Annals of Clinical and Translational Neurology, 7, 2082-2093. 2020. (IF 3.660)
  • Hayashi F, Isobe N, Glanville J, Matsushita T, Maimaitijiang G, Fukumoto S, Watanabe M, Masaki K, Kira J. A new clustering method identifies multiple sclerosis-specific T-cell receptors. Ann Clin Transl Neurol. 8(1):163-176. 2021 Jan. (IF 3.660)
  • Ogata H, Zhang X, Inamizu S, Yamashita K, Yamasaki R, Matsushita T, Isobe N, Hiwatashi A, Tobimatsu S, Kira J. Optic, trigeminal and facial neuropathy related to anti-neurofascin 155 antibody. Annals of Clinical and Translational Neurology, 7(11), 2297-2309. 2020. (IF 3.660)
  • Ogata H, Isobe N, Zhang X, Yamasaki R, Fujii T, Machida A, Morimoto N, Kaida K, Masuda T, Ando Y, Kuwahara M, Kusunoki S, Nakamura Y, Matsushita T, Kira J. Unique HLA haplotype associations in IgG4 anti-neurofascin 155 antibody-positive chronic inflammatory demyelinating polyneuropathy. Journal of Neuroimmunology, 339, 577139. 2020. (IF 3.125)
  • Matsuse D, Yamasaki R, Maimaitijiang G, Yamaguchi H, Masaki K, Isobe N, Matsushita T, Kira J. Early decrease in intermediate monocytes in peripheral blood is characteristic of multiple system atrophy-cerebellar type. Journal of Neuroimmunology, 349, 577395. 2020. (IF 3.125)
  • Fujii T, Yamasaki R, Miyachi Y, Nagata S, Maimaitijiang G, Nakamura Y, Shinoda K, Matsushita T, Isobe N, Kira J. Central nervous system-specific antinuclear antibodies in patients with multiple sclerosis. Journal of the Neurological Sciences, 409, 116619. 2020. (IF 3.115)
  • Fukumoto S, Nakamura Y, Watanabe M, Isobe N, Matsushita T, Sakoda A, Hiwatashi A, Shinoda K, Yamasaki R, Tsujino A, Kira J. Risk HLA-DRB1 alleles differentially influence brain and lesion volumes in Japanese patients with multiple sclerosis. Journal of the Neurological Sciences, 413, 116768. 2020. (IF 3.115)
  • Sadashima S, Honda H, Suzuki SO, Shijo M, Aishima S, Kai K, Kira J, Iwaki T. Accumulation of astrocytic aquaporin 4 and aquaporin 1 at prion protein plaques in Gerstman-Sträussler-Scheinker disease. Journal of Neuropathology and Experimental Neurology, 79(4), 419-429. 2020. (IF 2.923)
  • Sakoda A, Matsushita T, Nakamura Y, Watanabe M, Shinoda K, Masaki K, Isobe N, Yamasaki R, Kira J. Environmental risk factors for multiple sclerosis in Japanese people. Mult Scler Relat Disord, 38:101872. 2020. (IF 2.889)
  • Inamizu S, Yamada E, Ogata K, Uehara T, Kira J, Tobimatsu S. Neuromagnetic correlates of hemispheric specialization for face and word recognition. Neuroscience Research, 156, 108-116. 2020. (IF 2.645)
  • Tanaka K, Matsumoto S, Furuta K, Yamada T, Nagano S, Takase K, Hatano T, Yamasaki R, Kira J. Modified diffusion-weighted imaging-Alberta Stroke Program Early Computed Tomography Score including deep white matter lesion predicts symptomatic intracranial hemorrhage following intravenous thrombolysis. Journal of Thrombosis and Thrombolysis, 50(1), 174-180. 2020. (IF 2.123)
  • Tanaka K, Matsumoto S, Furuta K, Yamada T, Nagano S, Takase K, Hatano T, Yamasaki R, Kira J. Differences between predictive factors for early neurological deterioration due to hemorrhagic and ischemic insults following intravenous recombinant tissue plasminogen activator. Journal of Thrombosis and Thrombolysis, 49(4), 545-550. 2020. (IF 2.123)
  • Hagiwara K, Ogata K, Hironaga H, Tobimatsu S: Secondary somatosensory area is involved in vibrotactile temporal-structure processing: MEG analysis of slow cortical potential shifts in humans. Somatosensory and Motor Research. 37(3):222-232. doi: 10.1080/08990220.2020.1784127. 2020. (IF 1.028)
  • Prawiroharjoa P, Yamashita K, Togao O, Hiwatashi A, Yamasaki R, Kira J. Disconnection of the right superior parietal lobule from the precuneus is associated with memory impairment in oldest-old Alzheimer’s disease patients. Heliyon, 6(7), e04516. 2020. (IF未だなし)
  • Une H, Matsuse D, Uehara T, Kikuchi Y, Inamizu S, Yamasaki R, Tobimatsu S, Shibasaki H, Kira J. Branchial myorhythmia in a case of systemic lupus erythematosus. Journal of the Neurological Sciences, 408, 116501. 2020. (IF 3.115)
  • Yamasaki R, Yonekawa T, Inamizu S, Shinoda K, Ochi H, Matsushita T, Isobe N, Tsuji G, Sadashima S, Kuma Y, Oda Y, Iwaki T, Furue M, Kira J. A case of overlapping adult-onset linear scleroderma and Parry-Romberg syndrome presenting with widespread ipsilateral neurogenic involvement. Neuropathology, 40(1), 109-115. 2020. (IF 1.758)
  • Yanagihara Y, Hayashi S, Koge J, Honda H, Yamasaki R, Yamada Y, Oda Y, Iwaki T, Kira J. Immunotherapy-refractory vacuolar myopathy with mucin deposition in scleromyxedema: a possible role of fibroblast growth factor 2. Neuropathology, 40(5), 492-495. 2020. (IF 1.758)
  • Yoshimura M, Uehara T, Tanaka E, Okadome T, Yamaguchi T, Maeda Y, Isobe N, Matsushita T, Yamasaki R, Kira J. Double positivity for anti-N-methyl-D-aspartate receptor and anti-aquaporin-4 antibodies in a patient presenting with hypersomnolence, personality change and reduced spontaneity. Clinical and Experimental Neuroimmunology, 11(S1), 53-56. 2020. (IF未だなし)
  • 前田泰宏, 渡邉充, 前田教寿, 緒方英紀, 篠田紘司, 岩城徹, 吉良潤一. 免疫抑制薬使用患者に生じた重症水痘。帯状疱疹ウイルス関連脳脊髄炎の1剖検例. 臨床神経学, 60, 351-357. 2020.
  • Kira J, Isobe N. Multiple Sclerosis. Neuroimmune diseases; from cells to the living brain. Mitoma H, Manto M (Eds.), Springer Nature, pp. 487-521, 2020.
  • Fujii T, Yamasaki R, Miyachi Y, Iinuma K, Kira J. Anti-plexin D1 antibody-mediated neuropathic pain. Clinical and Experimental Neuroimmunology, 11(S1), 48-52. 2020. (IF 未だなし)
  • Masaki K. Recent advances in understanding connexin gap junction pathology in demyelinating diseases. Clinical and Experimental Neuroimmunology, 11(S1), 4-13. 2020. (IF 未だなし)
  • 吉良潤一. 福岡県難病診療連携拠点病院の指定と全国初の未診断・未指定難病相談支援センターの開設. ほすぴたる, 744, 5-6. 2020.
  • 磯部紀子, 吉良潤一. 免疫性神経疾患update ―基礎・臨床研究の最新知見―. 多発性硬化症・視神経脊髄炎の疫学. 日本臨牀, 78 (11), 1811-1816. 2020.
  • 山﨑亮, 吉良潤一. 慢性炎症性脱髄性多発神経炎(CIDP)と多巣性運動性ニューロパチー(MMN). 別冊BIO Clinica 慢性炎症と疾患, 25(9), 34-39. 2020.
  • 渡邉充, 吉良潤一. ミエリンベーシック蛋白（MBP）. 内科（増大号：検査値を読む2020）, 125(4), 1116. 2020.
  • 渡邉充，吉良潤一．多発性硬化症．お医者さんオンライン．永井良三，大曲貴夫，神田善伸他，プレシジョン，2020.
  • 藤井敬之, 宮地佑希野．抗Plexin D1抗体．日本臨牀 2020; 78: 1945-1950. 2020.
  • 藤井敬之, 山﨑亮, 宮地佑希野, 飯沼今日子, 吉良潤一．抗plexin D1抗体に関連した神経障害性疼痛．末梢神経 2020; 31: 62-68. 2020.
  • 今村友裕．精神疾患 (認知症, うつ, 睡眠障害など) の予防・治療における漢方の役割，PROGRESS IN MEDICINE 40 (9)，955-959. 2020.
  • 今村友裕．漢方トゥデイ、印象に残る症例（認知症患者の易怒性に対して漢方が奏功した症例）．ラジオNIKKEI第2．2020/10/1放送
  • 今村友裕．漢方トゥデイ、印象に残る症例（認知症におけるBPSDの陰性症状の改善に漢方が有効であった症例）．ラジオNIKKEI第2．2020/11/5放送
  • 福元尚子, 渡邉充, 吉良潤一. ライム病（スピロヘータ）. Clinical Neuroscience, 38 (10), 1234-1235. 2020.

過去の業績

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