九州大学大学院医学研究院神経内科学教室

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ACTIVITY REPORT活動報告

研究業績

2013年度業績

  • Yoshimura S*, Isobe N*, Matsushita T, Yonekawa T, Masaki K, Sato S, Kawano Y, Kira J: Distinct genetic and infectious profiles in Japanese neuromyelitis optica patients according to anti-aquaporin-4 antibody status. J Neurol Neurosurg Psychiatry 84: 29-34, 2013.
  • Soejima N, Ohyagi Y, Nakamura N, Himeno E, Iinuma KM, Sakae N, Yamasaki R, Tabira T, Murakami K, Irie K, Kinoshita N, LaFerla FM, Kiyohara Y, Iwaki T, Kira J: Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer’s disease. Current Alzheimer Research 10: 11-20, 2013.
  • Nagara Y, Tateishi T, Yamasaki R, Hayashi S, Kawamura M, Kikuchi H, Motomura Iinuma K, Tanaka M, Iwaki T, Matsushita T, Ohyagi Y, Kira J:Impaired cytoplastic-nuclear transport of hypoxia-inducible factor-1αin amgotrophic lateral sclerosis. Brain Pathol 23: 534-546, 2013.
  • Huang J, Yoshimura S, Isobe N, Matsushita T, Yonekawa T, Sato S, Yamasaki R, Kira J: A NOTCH4 missense mutation confers resistance to multiple sclerosis in Japanese. Multiple Sclerosis 19: 1696-1703, 2013.
  • Isobe N, Yonekawa T, Matsushita T, Masaki K, Yoshimura S, Fichna J, Chen S, Furmania K, Smith BR, Kira J: Clinical relevance of serum aquaporin-4 levels in neuromyelitis optica. Neurochem Res 38: 997-1001, 2013.
  • Matsushita T, Tateishi T, Isobe N, Yonekawa T, Yamasaki R, Murai H, Kira J: Characteristic cerebrospinal fluid cytokine/chemokine profiles in neuromyelitis optica, relapsing remitting or primary progressive multiple sclerosis. PLoS ONE 8(4): e61835, 2013.
  • Huang J, Isobe N, Matsushita T, Yoshimura S, Sato S, Yonekawa T, Yamasaki R, Kira J: Distinct genetic profiles between Japanese multiple sclerosis patients with and without Barkhof brain lesions. Clin Exp Neuroimmunol 4: 173-180, 2013.
  • Kanamori Y, Isobe N, Yonekawa T, Matsushita T, Shigeto H, Kawamura N, Yamasaki R, Murai H, Tobimatsu S, Kira J: Multimodality evoked potentials for discrimination of atopic myelitis and multiple sclerosis. Clin Exp Neuroimmunol 4: 29-35, 2013.
  • Kamada T, Sun W, Takase K, Shigeto H, Suzuki SO, Ohyagi Y, Kira J: Spontaneous Seizures in a Rat Model of Multiple Prenatal Freeze Lesioning. Epilepsy Res 105: 280-291, 2013.
  • Kanamori Y, Hironaga N, Hagiwara K, Uehara T, Chatani H, Sakata A, Hashiguchi K, Morioka T, Tobimatsu S, Kira J: Minimum norm estimates analysis in MEG can delineate the onset of interictal epileptic discharges: a comparison with ECoG findings. Neuro Image: Clinical 22: 663-669, 2013.
  • Kawamura N*, Yamasaki R*, Yonekawa T, MatsushitaT, Kusunoki S, Nagayama S, Fukuda Y, Ogata H, Matsuse D, Murai H, Kira J: Anti-neurofascin antibody in patients with combined central and peripheral demyelination. Neurology 81: 714-722, 2013. *Both contributed equally to this work.
  • Watanabe M, Yamasaki R, Kawano Y, Imamura S, Kira J: Anti-KIR4.1 Antibodies in Japanese Patients with Multiple Sclerosis. Clin Exp Neuroimmunol 4: 241-242, 2013.
  • Cui YW, Kawano Y, Shi N, Masaki K, Isobe N, Yonekawa T, Matsushita T, Tateishi T, Yamasaki R, Murai H, Kira J: Alterations in chemokine receptor expressions on peripheral blood monocytes in multiple sclerosis and neuromyelitis optica. Clin Exp Neuroimmunol 4: 201-205, 2013.
  • Yoshimura S, Yonekawa T, Isobe N, Matsushita T, Kira J: Bacterial infectious burden and prevalence of idiopathic central nervous system demyelinating diseases in Japanese. Clin Exp Neuroimmunol 4: 351-352, 2013.
  • Masaki K, Suzuki SO, Matsusita T, Matsuoka T, Imamura S, Yamasaki R, Suzuki M, Suenaga T, Iwaki T, Kira J: Connexin 43 astrocytopathy linked to rapidly progressive multiple sclerosis and neuromyelitis optica. PLoS ONE 8(4): e61835, 2013.
  • Kawano Y*, Matsushita T*, Cui YW, Isobe M, Yoshimura S, Yonekawa T, Masaki K, Yamasaki R, Murai H, Kira J: The protein kinase C-η polymorphism rs2230500 does not confer disease susceptibility to multiple sclerosis or neuromyelitis optica. Clin Exp Neuroimmunol 4: 283-287, 2013. *both contributed equally to this work.
  • Kira J, Yamasaki R, Yoshimura S, Fukazawa T, Yokoyama K, Fujihara K, Ogino M, Yokota T, Miyamoto K, Niino M, Nomura K, Tomioka R, Tanaka M, Kawachi I, Ohashi T, Kaita K, Matsui M, Nakatsuji Y, Ochi H, Kanda T, Nagaishi A, Togo K, Mizusawa H, Kawano Y: Efficacy of methylprednisolone pulse therapy for acute relapse in Japanese patients with multiple sclerosis and neuromyelitis optica: a multicenter retrospective analysis: 1. Whole group analysis. Clin Exp Neuroimmunol 4: 305-317, 2013.
  • Taniwaki T, Yoshiura T, Ogata K, Togao O, Yamashita K, Kida H, Miura S, Kira J, Tobimatsu S: Disrupted connectivity of motor loops in Parkinson’s disease during self-initiated but not externally-triggered movements. Brain Reseach 1512: 45-59, 2013.
  • 松下拓也、吉村怜、小副川学、吉良潤一：第4回多発性硬化症全国臨床疫学調査による日本における多発性硬化症の治療実態の解析．神経治療学 30(1): 67-70, 2013.
  • 田中弘二、立石貴久、河村信利、大八木保政、浦田美秩代、吉良潤一：ミトコンドリアDNAに多重欠失を認めたSensory ataxic neuropathy, dysarthria, and ophthalmoparesisの１例．臨床神経 53: 205-211, 2013．
  • 鎌田崇嗣、立石貴久、山下珠代、詠田眞治、大八木保政、吉良潤一：痙性対麻痺を呈した椎骨動脈蛇行による延髄圧迫の１例．臨床神経　53: 356-361, 2013．山崎貴男、椎裕章、吉良潤一：急性中毒症が明らかでなく初期診断が困難であった間欠型一酸化炭素中毒の１例：急性発症性認知症の鑑別診断．認知神経科学　Vol.14  No.3. 193-197, 2013．
  • 岩永育貴、林信太郎、河村信利、大八木保政、吉良潤一：限局皮膚硬化型全身性強皮症とシェーグレン症候群にneuromyelitis optica spectrum disorderを合併した１例．臨床神経 53: 695-700, 2013．
  • Sonoda K, Yamasaki R, Matsushita T, Yoshimura T, Murai H, Kira J:A case of CLIPPERS showing features common to multiple sclerosis.Clin Exp Neuroimmunol 4: 104-106, 2013.
  • Saitoh B, Yamasaki R, Hayashi S, Yoshimura S, Tateishi T, Ohyagi Y, Murai H, Iwaki T, Yoshida K, Kira J: A case of hereditary diffuse leukoencephalopathy with axonal spheroids caused by a de novo mutation in CSF1R masquerading as primary progressive multiple sclerosis. Mult Scler 19: 1367-1370, 2013.
  • Shiraishi W, Hayashi S, Kamada T, Murai H, Ohyagi Y, Kira J:Shower embolism-like brain lesions in Churg-Strauss syndrome. Clin Exp Neuroimmunol 4: 348-350, 2013.
  • Sonoda K, Sasaki K, Tateishi T, Yamasaki R, Hayashi S, Sakae N, Ohyagi Y, Iwaki T, Kira J: TAR DNA-binding protein 43 pathology in a case clinically diagnosed with facial-onset sensory and motor neuronopathy syndrome: an autopsied case report and a review of the literature.J Neurol Sci 322: 148-153, 2013.
  • Suzuki M, Kawasaki H, Masaki K, Suzuki SO, Terada T, Tsuchida T, Tokuyama T, Kono S, Komori T, Baba S, Kira J, Miyajima H: An autopsy case of the Marburg variant of multiple sclerosis (acute multiple sclerosis). Intern Med 52: 1825-1832, 2013.
  • Yamashita C, Shigetou H, Maeda N, Kawaguchi M, Uryu M, Motomura S, Kira J:Transient interhemispheric disconnection in a case of insulinoma-induced hypoglycemic encephalopathy. J Neurol Sci 335: 233-237, 2013.
  • Saitoh B, Yoshida K, Hayashi S, Yamasaki R, Sato S, Kamada T, Suzuki SO, Murai H, Iwaki T, Ikeda S, Kira J: Sporadic hereditary diffuse leukoencephalopathy with axonal spheroids showing numerous lesions with restricted diffusivity caused by a novel splice site mutation in the CSF1R gene. Clin Exp Neuroimmunology 4 (Suppl.1): 76-81, 2013.
  • 吉村怜、吉良潤一：免疫抑制薬．医薬ジャーナル増刊号「新薬展望2013」49:321-329, 2013．
  • 渡邉充、吉良潤一：多発性硬化症．免疫反応と疾患．Medicina 50: 454-457, 2013.
  • 佐藤眞也、吉良潤一：免疫性神経疾患の感受性因子と抵抗因子．日本臨牀71: 873-788, 2013.
  • 河野祐治、吉良潤一：髄液ミエリン塩基性蛋白．内科．検査値を読む2013．南江堂 111: 1629, 2013.
  • 松瀬大、吉良潤一：多発性硬化症．神経・精神疾患診療マニュアル．日本医師会雑誌．142巻特別号（2）（生涯教育シリーズ85）: 218-219, 2013.
  • 渡邉充、吉良潤一：MSとNMOの治療の将来展望．Pharma Medica 31: 53-57, 2013.
  • 林信太郎、吉良潤一：エコーウイルス．神経症候群I －その他の神経疾患を含めて－[第２版]．日本臨牀　別冊　578-581, 2013.
  • 村井弘之、吉良潤一：レプトスピラ症．神経症候群I －その他の神経疾患を含めて－[第２版]．日本臨牀　別冊 852-854, 2013.
  • 河野祐治、吉良潤一：ボレリア．神経症候群I －その他の神経疾患を含めて－[第２版]．日本臨牀　別冊 855-858, 2013.
  • 村井弘之、吉良潤一：EBウィルスと中枢神経症状．成人病と生活習慣病 43: 1100-1102, 2013.
  • Kira J:Genetic and environmental factors underlying the rapid changes in epidemiological and clinical features of multiple sclerosis and neuromyelitis optica in Japanese. Clin Exp Neuroimmunol 4: 261-273, 2013.
  • 緒方英紀、吉良潤一：日本における多発性硬化症の特徴と変遷．脳２１．16: 434-438, 2013．
  • Kira J:Therapeutic benefits of an oral vitamin B1 derivative for human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)．BMC Medicine 11: 183-185, 2013.
  • 吉良潤一：運動性ニューロン病．神中整形外科学　改訂23版．岩本幸英（編）．南山堂 pp765-768, 2013.
  • 吉良潤一：若年性上肢遠位筋萎縮症（平山病）．神中整形外科学　改訂23版．岩本幸英（編）．南山堂 pp768, 2013.
  • 吉良潤一：シャルコー・マリー・ツース病．神中整形外科学　改訂23版．岩本幸英（編）．南山堂 pp769, 2013.
  • 吉良潤一：脊髄小脳変性症．神中整形外科学　改訂23版．岩本幸英（編）．南山堂 pp770, 2013.
  • 吉良潤一：多発性硬化症．神中整形外科学　改訂23版．岩本幸英（編）．南山堂 pp771, 2013.
  • 吉良潤一：多発性硬化症．今日の神経疾患治療指針．第2版  水澤英洋、鈴木則宏、梶龍兒、吉良潤一、神田隆、齊藤延人（編）．医学書院　pp. 528-533, 2013.
  • 吉良潤一：視神経脊髄炎．今日の治療指針2013年版―私はこう治療している．山口徹、北原光夫、福井次矢（編）．医学書院　pp. 808-809, 2013.
  • 松瀬大、吉良潤一：多発性硬化症．免疫性神経疾患ハンドブック 楠進(編)  南江堂pp.68-89, 2013.
  • 立石貴久、岩木三保、吉良潤一：難病医療ネットワークと地域ケアの実際を知る．新ＡＬＳケアブック・第二版．日本ＡＬＳ協会　第9章1節pp.245-254, 2013.
  • 立石貴久、吉良潤一：ＡＬＳのバイオマーカー．シリーズ（アクチュアル脳・神経疾患の臨床）．すべてがわかる筋委縮性側専硬化症・運動ニューロン疾患．辻省次（総編集）．祖父江元（責任編集）．中山書店 pp. 260-265, 2013.
  • 雑賀徹、吉良潤一：ＡＬＳ４(Serataxin 遺伝子異変によるＡＬＳ)．シリーズ（アクチュアル脳・神経疾患の臨床）．すべてがわかる筋委縮性側専硬化症・運動ニューロン疾患．辻省次（総編集）．祖父江元（責任編集）．中山書店pp.356-360, 2013.
  • 吉村怜、宮坂信之、吉良潤一：ステロイド診療マニュアル．新興医学出版社2013.
  • 山崎亮、吉良潤一：多発性硬化症．免疫疾患イラストレイテッド．田中良哉（編）．羊土社 pp. 218-226, 2013.
  • 山崎亮、吉良潤一：G-CSFの中枢神経保護作用．G-CSFS（顆粒球コロニー刺激因子）の基礎と臨床．東條有伸（編）．医薬ジャーナルpp. 53-64, 2013.
  • 河野祐治、吉良潤一：多発性硬化症・視神経脊髄炎．希少疾患ライブラリー．ケアネットドットコム(http://www.carenet.com)．2013年オンライン出版．
  • Kira J:Neuroinflammaiton in Neurological Disorders Neuron-Glia Interaction in Neuro-inflammation. Advances in Neurobiology 7.  Akio Suzumura, Kazuo Ikenaka (Editor) Springer 21-48, 2013.

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